|
|
3,3,5''-triiodo-L-thyronine + I- + acceptor + H+ <=> L-thyroxine + reduced_acceptor
|
1.21.99.3
thyroxine 5-deiodinase
1.21.99.4
thyroxine 5'-deiodinase
|
–
–
|
M
|
|
BRENDA:
BR47629;
BR48042;
BS356010;
BS356011
KEGG:
R03734;
R07230
MetaCyc:
1.97.1.11-RXN;
THYROXINE-DEIODINASE-RXN
SABIO-RK:
3494;
9212
|
|
|
|
L-thyroxine + 3''-phosphoadenylyl-sulfate <=> adenosine_3,5''-bisphosphate + H+ + L-thyroxine_4'-sulfate
|
2.8.2.1
aryl sulfotransferase
|
–
|
M
|
|
BRENDA:
BS379001
MetaCyc:
RXN-10614
|
|
|
|
UDP-glucuronate + L-thyroxine <=> thyroxine_beta-D-glucuronoside + UDP + H+
|
2.4.1.17
glucuronosyltransferase
|
–
|
M
|
|
BRENDA:
BS399092
MetaCyc:
RXN-10606;
RXN-10608
|
|
|
|
2 3,5-diiodo-L-tyrosine + H2O2 <=> L-thyroxine + 2-aminoacrylate + 2 H2O
|
1.11.1.8
iodide peroxidase
|
–
|
K
|
|
KEGG:
R03208
|
|
|
|
[thyroglobulin]-L-thyroxine <=> L-thyroxine
|
not assigned
|
–
|
|
|
KEGG:
R08525
|
|
|
|
[thyroglobulin]-L-thyroxine + H2O <=> L-thyroxine + [unspecified_degradation_products]
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-10477
|
|
|
|
L-thyroxine <=> Tetraiodothyroacetic_acid
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-10610
|
|
|
|
L-thyroxine <=> 3-iodothyronamine
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-10612
|
|
|
|
L-thyroxine + H2O + O2 <=> 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + NH3 + H2O2
|
1.4.3.2
L-amino-acid oxidase
|
–
|
|
|
BRENDA:
BS259011
|
|
|
|
UDP-glucuronate + L-thyroxine <=> UDP + L-thyroxyl_beta-D-glucuronoside
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
|
BRENDA:
BS436042
|
|
|
|
L-thyroxine + S-adenosyl-L-methionine <=> 3,5,3''5''-tetraiodo-O''-methyl-L-thyronine + S-adenosyl-L-homocysteine
|
2.1.1.26
iodophenol O-methyltransferase
|
–
|
|
|
BRENDA:
BS319676
|
|
|
|
L-thyroxine + 2-oxoglutarate <=> 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate
|
2.6.1.26
thyroid-hormone transaminase
|
–
|
|
|
BRENDA:
BS356393
|
|
|
|
L-thyroxine + electron_acceptor <=> 3,3'',5-triiodothyronine + I- + reduced_electron_acceptor
|
1.21.99.4
thyroxine 5'-deiodinase
|
–
|
|
|
BRENDA:
BS375171
|
|
|
|
3''-phosphoadenylylsulfate + L-thyroxine <=> adenosyl_3'',5''-bisphosphate + O-[3,5-diiodo-4-(sulfooxy)phenyl]-3,5-diiodotyrosine
|
2.8.2.15
steroid sulfotransferase
|
–
|
|
|
BRENDA:
BS379015
|
|